Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.

ABSTRACT:

Background and aims

Diverticulosis is a common disease of not completely defined pathogenesis. Motor abnormalities of the intestinal wall have been frequently described but very little is known about their mechanisms. We investigated in vitro the neural response of colonic longitudinal muscle strips from patients undergoing surgery for complicated diverticular disease (diverticulitis).

Methods

The neural contractile response to electrical field stimulation of longitudinal muscle strips from the colon of patients undergoing surgery for colonic cancer or diverticulitis was challenged by different receptor agonists and antagonists.

Results

Contractions of colonic strips from healthy controls and diverticulitis specimens were abolished by atropine. The beta adrenergic ago

SUBMITTER: Guagnini F 

PROVIDER: S-EPMC1856307 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature