Lack of association of MYO9B genetic variants with coeliac disease in a British cohort.

ABSTRACT:

Background and aims

Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association explains only a minority of disease heritability. A recent study in the Dutch population suggested that genetic variation in the 3' region of myosin IXB (MYO9B) predisposes to coeliac disease. MYO9B is a Rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation.

Methods

Four single nucleotide polymorphisms were chosen to tag all common haplotypes of the

SUBMITTER: Hunt KA 

PROVIDER: S-EPMC1856329 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature