Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility.

ABSTRACT:

Background

Previously, proteomic methods were applied to characterise differentially expressed proteins in microdissected pancreatic ductal adenocarcinoma cells.

Aims

To report that CapG and a related protein, gelsolin, which have established roles in cell motility, are overexpressed in metastatic pancreatic cancer; and to describe their pattern of expression in pancreatic cancer tissue and their effect on cell motility in pancreatic cancer cell lines.

Methods

CapG was identified by mass spectrometry and immunoblotting. CapG and gelsolin expression was assessed by immunohistochemical analysis on a pancreatic cancer tissue microarray and correlated with clinical and pathological parameters. CapG and gelsolin levels were reduced using RNA interface in Suit-2, Panc-1 and

SUBMITTER: Thompson CC 

PROVIDER: S-EPMC1856675 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature