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Ciona intestinalis as a model for cardiac development.

ABSTRACT: The primitive chordate Ciona intestinalis has emerged as a significant model system for the study of heart development. The Ciona embryo employs a conserved heart gene network in the context of extremely low cell numbers and reduced genetic redundancy. Here, I review recent studies on the molecular genetics of Ciona cardiogenesis as well as classic work on heart anatomy and physiology. I also discuss the potential of employing Ciona to decipher a comprehensive chordate gene network and to determine how this network controls heart morphogenesis.

SUBMITTER: Davidson B 

PROVIDER: S-EPMC1857341 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Ciona intestinalis as a model for cardiac development.

Davidson Brad B  

Seminars in cell & developmental biology 20061220 1

The primitive chordate Ciona intestinalis has emerged as a significant model system for the study of heart development. The Ciona embryo employs a conserved heart gene network in the context of extremely low cell numbers and reduced genetic redundancy. Here, I review recent studies on the molecular genetics of Ciona cardiogenesis as well as classic work on heart anatomy and physiology. I also discuss the potential of employing Ciona to decipher a comprehensive chordate gene network and to determ  ...[more]

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