The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.

ABSTRACT: A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was reproduced in four additional cohorts, but was not seen in a fifth cohort. To further assess the general reproducibility of this association, we genotyped rs7566605 in nine large cohorts from eight populations across multiple ethnicities (total n = 16,969). We tested this variant for association with BMI in each sample under a recessive model using family-based, population-based, and cas

SUBMITTER: Lyon HN 

PROVIDER: S-EPMC1857727 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature