The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva.

ABSTRACT: Regulation of spatio-temporal gene expression in diverse cell and tissue types is a critical aspect of development. Progression through Caenorhabditis elegans vulval development leads to the generation of seven distinct vulval cell types (vulA, vulB1, vulB2, vulC, vulD, vulE, and vulF), each with its own unique gene expression profile. The mechanisms that establish the precise spatial patterning of these mature cell types are largely unknown. Dissection of the gene regulatory networks involved in vulval patterning and differentiation would help us understand how cells generate a spatially defined pattern of cell fates during organogenesis. We disrupted the activity of 508 transcription factors via RNAi and assayed the expression of ceh-2, a marker for vulB fate during the L4 stage. From th

SUBMITTER: Fernandes JS 

PROVIDER: S-EPMC1857733 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature