Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the effect of oral decontamination on the incidence of ventilator associated pneumonia and mortality in mechanically ventilated adults.

Design

Systematic review and meta-analysis.

Data sources

Medline, Embase, CINAHL, the Cochrane Library, trials registers, reference lists, conference proceedings, and investigators in the specialty.

Review methods

Two independent reviewers screened studies for inclusion, assessed trial quality, and extracted data. Eligible trials were randomised controlled trials enrolling mechanically ventilated adults that compared the effects of daily oral application of antibiotics or antiseptics with no prophylaxis.

Results

11 trials totalling 3242 patients met the inclusion criteria. Among four trials with 109

SUBMITTER: Chan EY 

PROVIDER: S-EPMC1857782 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature