Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi.

ABSTRACT: Mural thrombi are composed dominantly of platelets and develop under a blood flow. Portions can break off and are carried in the blood flow as emboli. Thrombus growth rates are affected by the velocity of the blood flow, but they do not simply increase with it, they exhibit a maximum, with subsequent decrease. Whereas this variation indicates an interaction of biochemical and physical processes, studies have concentrated widely on understanding only the biochemical processes. Here we show results of simulation of thrombus formation in 3D flows by accounting for the movements of individual platelets. Each platelet follows prescribed rules for interactions while the local flow around the thrombus continuously adjusts to the growing structure of the thrombus, also when embolization occurs. Wi

SUBMITTER: Pivkin IV 

PROVIDER: S-EPMC1859903 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature