Human growth hormone (GH1) gene polymorphism map in a normal-statured adult population.

ABSTRACT:

Objective

GH1 gene presents a complex map of single nucleotide polymorphisms (SNPs) in the entire promoter, coding and noncoding regions. The aim of the study was to establish the complete map of GH1 gene SNPs in our control normal population and to analyse its association with adult height.

Design, subjects and measurements

A systematic GH1 gene analysis was designed in a control population of 307 adults of both sexes with height normally distributed within normal range for the same population: -2 standard deviation scores (SDS) to +2 SDS. An analysis was performed on individual and combined genotype associations with adult height.

Results

Twenty-five SNPs presented a frequency over 1%: 11 in the promoter (P1 to P11), three in the 5'UTR region (P12 to P14), one in ex

SUBMITTER: Esteban C 

PROVIDER: S-EPMC1859974 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature