Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients.

ABSTRACT:

Background

Severe acute respiratory syndrome (SARS) is an infectious disease which was caused by a novel coronavirus (SARS-CoV). SARS has caused an outbreak in the world during 2003 and 2004, with 8098 individuals being infected and a death toll of 774 in 28 regions around the world. Specific humoral responses to viral infection remain unclear.

Objective

To analyse the antigenicity of the SARS-CoV genome and identify potential antigenic epitopes in the structural proteins.

Methods

Potential antigenic epitopes were identified in the structural proteins (nucleocapsid, membrane, spike, and small envelope proteins) and hypothetical proteins (SARS3a, 3b, 6, 7a, and 9b) that are specific for SARS-CoV. A peptide chip platform was created and the profiles of antibodies to the

SUBMITTER: Chow SC 

PROVIDER: S-EPMC1860290 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature