Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours.

ABSTRACT:

Background

Nestin, one of the intermediate filaments constituting the cytoskeleton, is a marker of neural stem cells or progenitor cells. Its expression is also related to tooth development and repair of dentine.

Aims

The aim of this study was to investigate nestin expression in various odontogenic tumours and evaluate its usefulness for histopathological diagnosis.

Methods

We studied formalin fixed, paraffin embedded specimens from 129 cases of odontogenic tumours and 9 of mandibular intraosseous myxoma. After characterisation of odontogenic ectomesenchymal tissues in these tumours using antibodies to vimentin, desmin, neurofilament, and glial fibrillary acidic protein, we immunohistochemically examined nestin expression.

Results

No differentiation towards mus

SUBMITTER: Fujita S 

PROVIDER: S-EPMC1860355 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature