The predicting role of substance P in the neoplastic transformation of the hypoplastic bone marrow.

ABSTRACT:

Aims

To estimate the expression of substance P in the haematopoietic cells of hypoplastic bone marrow and define its relationship with the course of bone marrow hypoplasia.

Methods

Bone marrow specimens were obtained from 42 children with bone marrow hypoplasia who were hospitalised in the Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, Poland, between 1996 and 2003. Substance P and Ki-67 expression were evaluated using immunochemical and hybridocytochemical assays.

Results

The expression of substance P (as evidenced by both immunocytochemical and hybridisation techniques) was confirmed in the cytoplasm of B lymphocytes in 8 of 11 children who developed acute leukaemia in 45 (SD 12) days. The percentage

SUBMITTER: Nowicki M 

PROVIDER: S-EPMC1860490 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature