Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma.

ABSTRACT:

Background

For breast and prostate cancer, a gene expression signature of the tumour is associated with the development of distant metastases. Regarding head and neck squamous cell carcinoma (HNSCC), the only known risk factor is the presence of > or =3 tumour-positive lymph nodes.

Aim

To evaluate whether a HNSCC gene expression signature can discriminate between the patients with and without distant metastases.

Methods

Patients with HNSCC with and without distant metastases had >3 tumour-positive lymph nodes, and did not differ with respect to other risk factors. Statistical analysis was carried out using Student's t test, as well as statistical analysis of microarrays (SAM), to assess the false discovery rate for each gene. These analyses were supplemented with a ne

SUBMITTER: Braakhuis BJ 

PROVIDER: S-EPMC1860543 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature