Reduced levels of oestrogen receptor beta mRNA in Swedish patients with chronic fatigue syndrome.

ABSTRACT:

Background

Chronic fatigue syndrome (CFS) is an illness with unknown aetiology and pathophysiology. The difference in incidence by sex observed for CFS indicates a role for oestrogen and oestrogen receptors in disease development. Furthermore, an immunomediated pathogenesis has been suggested for CFS, providing an additional connection to oestrogen, which displays immunomodular functions.

Aims

To investigate a possible association of oestrogen receptor (ER) mRNAs and two ERbeta single-nucleotide polymorphisms (SNPs) with CFS.

Methods

Messenger RNA levels of ERalpha, ERbeta wt and ERbeta cx were investigated in peripheral blood mononuclear cells from 30 patients with CFS and 36 healthy controls by quantitative real-time polymerase chain reaction. Two ERbeta SNPs were s

SUBMITTER: Grans H 

PROVIDER: S-EPMC1860629 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature