Effect of left ventricular endocardial activation pattern on echocardiographic and clinical response to cardiac resynchronization therapy.

ABSTRACT:

Objective

To explore the left ventricular (LV) electrical activation pattern in heart failure (HF) and its implication to cardiac resynchronization therapy (CRT).

Design and setting

Observational study at the University Teaching Hospital.

Patients

23 optimally treated patients with HF with New York Heart Association class III, QRS duration >120 ms and LV ejection fraction <35%.

Interventions

The LV endocardial activation pattern and total activation time (Tat) was determined by non-contact mapping and the LV mechanical dys-synchrony was determined by standard deviation (Ts-SD) and maximal difference (Ts-diff) of time to peak systolic contraction (Ts) among 12 LV segments using tissue Doppler imaging before receiving CRT.

Main outcome measures

Correlation

SUBMITTER: Fung JW 

PROVIDER: S-EPMC1861475 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature