Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas.

ABSTRACT:

Background

The Allen Brain Atlas (ABA) project systematically profiles three-dimensional high-resolution gene expression in postnatal mouse brains for thousands of genes. By unveiling gene behaviors at both the cellular and molecular levels, ABA is becoming a unique and comprehensive neuroscience data source for decoding enigmatic biological processes in the brain. Given the unprecedented volume and complexity of the in situ hybridization image data, data mining in this area is extremely challenging. Currently, the ABA database mainly serves as an online reference for visual inspection of individual genes; the underlying rich information of this large data set is yet to be explored by novel computational tools. In this proof-of-concept study, we studied the hypothesis that genes sh

SUBMITTER: Liu Z 

PROVIDER: S-EPMC1863433 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature