Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

ABSTRACT: Emergence of bacterial resistance is a major issue for all classes of antibiotics; therefore, the identification of new classes is critically needed. Recently we reported the discovery of platensimycin by screening natural product extracts using a target-based whole-cell strategy with antisense silencing technology in concert with cell free biochemical validations. Continued screening efforts led to the discovery of platencin, a novel natural product that is chemically and biologically related but different from platensimycin. Platencin exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis. It does not exhibit cross-resistance to key antibiotic resistant strains tested, including methicillin-resistant Staphylococcus aureus, vancomycin-

SUBMITTER: Wang J 

PROVIDER: S-EPMC1863502 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature