Testing for HER2-positive breast cancer: a systematic review and cost-effectiveness analysis.

ABSTRACT:

Background

Testing to determine HER2 status has come into focus since the approval of trastuzumab (Herceptin) for the treatment of HER2-positive breast cancer. We compared the cost-effectiveness of various strategies used to test HER2 status, an important first step toward evaluating the overall cost-effectiveness of trastuzumab therapy.

Methods

We performed a systematic review of studies that evaluated concordance between immunohistochemistry and fluorescence in situ hybridization testing to determine HER2 status. We performed a meta-analysis to estimate the distribution of immunohistochemistry scores in each category (0, 1+, 2+, 3+) and the probability of receiving a positive result of fluorescence in situ hybridization (which we assumed to be the "gold-standard" test) for

SUBMITTER: Dendukuri N 

PROVIDER: S-EPMC1863543 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature