Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease.

ABSTRACT: GSTs are a family of inducible phase II enzymes that may play a neuroprotective role in Parkinson's disease (PD). GSTs may also modify PD risk by metabolizing compounds in cigarettes, as cigarette smoking is generally found to be associated with a decrease in PD risk. Using a population-based case-control study design, we examined polymorphisms of the mu, omega, pi, and theta classes of GST to elucidate the main effects and smoking-GST interactions on PD risk. From three rural California counties, we recruited 289 incident idiopathic PD cases, clinically confirmed by our study neurologist, and 270 population controls, marginally matched by age, gender, and race. We assessed main gene polymorphism associations and evaluated interactions between smoking and GST polymorphisms as departures fr

SUBMITTER: Wahner AD 

PROVIDER: S-EPMC1864949 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature