Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.

ABSTRACT: Drosophila melanogaster exhibits two expression-regulating systems that target whole, specific chromosomes: the dosage compensation system whereby the male-specific lethal complex doubles transcription of genes on the male X-chromosome and the chromosome 4-specific protein Painting of fourth, POF. POF is the first example of an autosome-specific protein and its presence raises the question of the universality of chromosome-specific regulation. Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome. Contrary to previous conclusions, Pof is not essential for survival of diplo-4th karyotype flies. However, Pof is essential for survival of haplo-4th individuals and expression of chromosome 4 genes in diplo-4th individuals is decrea

SUBMITTER: Johansson AM 

PROVIDER: S-EPMC1864965 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature