Cooperative gating and spatial organization of membrane proteins through elastic interactions.

ABSTRACT: Biological membranes are elastic media in which the presence of a transmembrane protein leads to local bilayer deformation. The energetics of deformation allow two membrane proteins in close proximity to influence each other's equilibrium conformation via their local deformations, and spatially organize the proteins based on their geometry. We use the mechanosensitive channel of large conductance (MscL) as a case study to examine the implications of bilayer-mediated elastic interactions on protein conformational statistics and clustering. The deformations around MscL cost energy on the order of 10 kBT and extend approximately 3 nm from the protein edge, as such elastic forces induce cooperative gating, and we propose experiments to measure these effects. Additionally, since elastic interac

SUBMITTER: Ursell T 

PROVIDER: S-EPMC1864995 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature