Vascular endothelial growth factor and angiopoietin are required for prostate regeneration.

ABSTRACT:

Background

The regulation of the prostate size by androgens may be partly the result of androgen effects on the prostatic vasculature. We examined the effect of changes in androgen levels on the expression of a variety of angiogenic factors in the mouse prostate and determined if vascular endothelial growth factor (VEGF)-A and the angiopoietins are involved in the vascular response to androgens.

Methods

Expression of angiogenic factors in prostate was quantitated using real-time PCR at different times after castration and after administration of testosterone to castrated mice. Angiopoietins were localized in prostate by immunohistochemistry and in situ hybridization. The roles of VEGF and the angiopoietins in regeneration of the prostate were examined in mice inoculated with

SUBMITTER: Wang GM 

PROVIDER: S-EPMC1865098 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature