NOGO-A induction and localization during chick brain development indicate a role disparate from neurite outgrowth inhibition.

ABSTRACT:

Background

Nogo-A, a myelin-associated protein, inhibits neurite outgrowth and abates regeneration in the adult vertebrate central nervous system (CNS) and may play a role in maintaining neural pathways once established. However, the presence of Nogo-A during early CNS development is counterintuitive and hints at an additional role for Nogo-A beyond neurite inhibition.

Results

We isolated chicken NOGO-A and determined its sequence. A multiple alignment of the amino acid sequence across divergent species, identified five previously undescribed, Nogo-A specific conserved regions that may be relevant for development. NOGO gene transcripts (NOGO-A, NOGO-B and NOGO-C) were differentially expressed in the CNS during development and a second NOGO-A splice variant was identified. We

SUBMITTER: Caltharp SA 

PROVIDER: S-EPMC1865376 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature