Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.

ABSTRACT:

Background

Genes involved in dopaminergic neurotransmission have been suggested as candidates for involvement in smoking behavior. We hypothesized that alleles associated with reduced dopaminergic neurotransmission would be more common in continuing smokers than among women who quit smoking.

Methods

The study included 593 women aged 26-65 years who participated in a twelve month smoking cessation trial conducted in 1993-1994. Participants were contacted three years after the trial to obtain updated smoking history and biological specimens. Seven polymorphisms were assessed in genes involved in dopamine synthesis (tyrosine hydroxylase [TH]), receptor activation (dopamine receptors [DRD2, DRD3, DRD4]), reuptake (dopamine transporter [SLC6A3]), and metabolism (catechol-o-methyl

SUBMITTER: Ton TG 

PROVIDER: S-EPMC1865548 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature