Hubs in biological interaction networks exhibit low changes in expression in experimental asthma.

ABSTRACT: Asthma is a complex polygenic disease involving the interaction of many genes. In this study, we investigated the allergic response in experimental asthma. First, we constructed a biological interaction network using the BOND (Biomolecular Object Network Databank) database of literature curated molecular interactions. Second, we mapped differentially expressed genes from microarray data onto the network. Third, we analyzed the topological characteristics of the modulated genes. Fourth, we analyzed the correlation between the topology and biological function using the Gene Ontology classifications. Our results demonstrate that nodes with high connectivity (hubs and superhubs) tend to have low levels of change in gene expression. The significance of our observations was confirmed by permutat

SUBMITTER: Lu X 

PROVIDER: S-EPMC1865580 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature