Developmental regulation of an adhesin gene during cellular morphogenesis in the fungal pathogen Candida albicans.

ABSTRACT: Candida albicans expresses specific virulence traits that promote disease establishment and progression. These traits include morphological transitions between yeast and hyphal growth forms that are thought to contribute to dissemination and invasion and cell surface adhesins that promote attachment to the host. Here, we describe the regulation of the adhesin gene ALS3, which is expressed specifically during hyphal development in C. albicans. Using a combination of reporter constructs and regulatory mutants, we show that this regulation is mediated by multiple factors at the transcriptional level. The analysis of ALS3 promoter deletions revealed that this promoter contains two activation regions: one is essential for activation during hyphal development, while the second increases the ampl

SUBMITTER: Argimon S 

PROVIDER: S-EPMC1865654 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature