Modelling the interaction of steroid receptors with endocrine disrupting chemicals.

ABSTRACT:

Background

The organic polychlorinated compounds like dichlorodiphenyltrichloroethane with its metabolites and polychlorinated biphenyls are a class of highly persistent environmental contaminants. They have been recognized to have detrimental health effects both on wildlife and humans acting as endocrine disrupters due to their ability of mimicking the action of the steroid hormones, and thus interfering with hormone response. There are several experimental evidences that they bind and activate human steroid receptors. However, despite the growing concern about the toxicological activity of endocrine disrupters, molecular data of the interaction of these compounds with biological targets are still lacking.

Results

We have used a flexible docking approach to characterize the

SUBMITTER: D'Ursi P 

PROVIDER: S-EPMC1866398 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature