Parallel construction of orthologous sequence-ready clone contig maps in multiple species.

ABSTRACT: Comparison is a fundamental tool for analyzing DNA sequence. Interspecies sequence comparison is particularly powerful for inferring genome function and is based on the simple premise that conserved sequences are likely to be important. Thus, the comparison of a genomic sequence with its orthologous counterpart from another species is increasingly becoming an integral component of genome analysis. In ideal situations, such comparisons are performed with orthologous sequences from multiple species. To facilitate multispecies comparative sequence analysis, a robust and scalable strategy for simultaneously constructing sequence-ready bacterial artificial chromosome (BAC) contig maps from targeted genomic regions has been developed. Central to this approach is the generation and utilization of

SUBMITTER: Thomas JW 

PROVIDER: S-EPMC186643 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature