A genome-wide scan using tree-based association analysis for candidate loci related to fasting plasma glucose levels.

ABSTRACT:

Background

In the analysis of complex traits such as fasting plasma glucose levels, researchers often adjust the trait for some important covariates before assessing gene susceptibility, and may at times encounter confounding among the covariates and the susceptible genes. Previously, the tree-based method has been employed to accommodate the heterogeneity in complex traits. In this study, we performed a genome-wide screen on fasting glucose levels in the offspring generation of the Framingham Heart Study provided by the Genetic Analysis Workshop 13. We defined one quantitative trait and converted it to a dichotomous trait based on a predetermined cut-off value, and performed association analyses using regression and classification trees for the two traits, respectively. A marker w

SUBMITTER: Chen CH 

PROVIDER: S-EPMC1866503 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature