Haplotype sharing correlation of alcohol dependence on chromosomes 1-6 in 93 nuclear families.

ABSTRACT: Haplotype data contain signatures of ancestral alleles and increased information for mapping genes associated with complex traits. The motivation of this paper is to test the feasibility of a recently developed haplotype reconstruction algorithm and to perform haplotype-sharing correlation (HSC) analysis in nuclear families using data provided by the Genetic Analysis Workshop 14 and the Collaborative Study of the Genetics of Alcoholism. As an exemplary analysis, haplotype data on chromosomes 1-6 were reconstructed from genotype data in 93 nuclear families by minimizing both the recombinants in within-family haplotypes and the tree distance in between-family haplotypes. HSC analysis was performed using the best set of reconstructed haplotypes, and chromosome-wide significance was evaluated

SUBMITTER: Qian D 

PROVIDER: S-EPMC1866702 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature