Gene expression screening of salivary gland neoplasms: molecular markers of potential histogenetic and clinical significance.

ABSTRACT: Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. The molecular events associated with their development and clinicopathological heterogeneity remain unknown. To reveal these events, we performed microarray expression analysis using a nylon-filter membrane platform on 18 primary lesions representing the most common benign and malignant types. Our study identified a small set of genes that are differentially altered between normal salivary gland tissues and benign and malignant tumors. Of the 5000 genes arrayed, 136 genes were differentially expressed by normal tissue, benign tumors, and various malignant neoplasms. Hierarchical clustering analysis differentiated between adenoid cystic carcinomas (ACCs) and other malignant subtypes.

SUBMITTER: Maruya S 

PROVIDER: S-EPMC1867638 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature