Gene discovery in bladder cancer progression using cDNA microarrays.

ABSTRACT: To identify gene expression changes along progression of bladder cancer, we compared the expression profiles of early-stage and advanced bladder tumors using cDNA microarrays containing 17,842 known genes and expressed sequence tags. The application of bootstrapping techniques to hierarchical clustering segregated early-stage and invasive transitional carcinomas into two main clusters. Multidimensional analysis confirmed these clusters and more importantly, it separated carcinoma in situ from papillary superficial lesions and subgroups within early-stage and invasive tumors displaying different overall survival. Additionally, it recognized early-stage tumors showing gene profiles similar to invasive disease. Different techniques including standard t-test, single-gene logistic regression, a

SUBMITTER: Sanchez-Carbayo M 

PROVIDER: S-EPMC1868230 | biostudies-literature | 2003 Aug

REPOSITORIES: biostudies-literature