Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants.

ABSTRACT: We have previously reported the pattern of cellular expression of tumor necrosis factor receptors (TNFR) in human kidney and their altered expression in transplant rejection. We have extended our studies to examine the expression of Silencer of Death Domains (SODD), a protein that binds to the cytoplasmic portion of TNFR1 to inhibit signaling in the absence of ligand. In normal human kidney SODD is expressed in glomerular endothelial cells where it colocalizes with TNFR1. During acute rejection both SODD and TNFR1 are lost from glomeruli, but we found strong expression of SODD on the luminal surface of tubular epithelial cells. This occurs in the absence of detectable TNFR1 expression, suggesting that SODD could interact with other proteins at these sites. Several other members of the TNF

SUBMITTER: Al-Lamki RS 

PROVIDER: S-EPMC1868232 | biostudies-literature | 2003 Aug

REPOSITORIES: biostudies-literature