Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins.

ABSTRACT: The sequential processing of the APP (amyloid precursor protein) by the beta- and gamma-secretase and generation of the Abeta (amyloid-beta) peptide is a primary pathological factor in AD (Alzheimer's disease). Regulation of the processing or turnover of these proteins represents potential targets for the development of AD therapies. Sumoylation is a process by which SUMOs (small ubiquitin-like modifiers) are covalently conjugated to target proteins, resulting in a number of functional consequences. These include regulation of protein-protein interactions, intracellular trafficking and protein stability, which all have the potential to impact on several aspects of the amyloidogenic pathway. The present study examines the effects of overexpression and knockdown of the major SUMO isoforms (S

SUBMITTER: Dorval V 

PROVIDER: S-EPMC1868795 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature