Polarity and intracellular compartmentalization of Drosophila neurons.

ABSTRACT:

Background

Proper neuronal function depends on forming three primary subcellular compartments: axons, dendrites, and soma. Each compartment has a specialized function (the axon to send information, dendrites to receive information, and the soma is where most cellular components are produced). In mammalian neurons, each primary compartment has distinctive molecular and morphological features, as well as smaller domains, such as the axon initial segment, that have more specialized functions. How neuronal subcellular compartments are established and maintained is not well understood. Genetic studies in Drosophila have provided insight into other areas of neurobiology, but it is not known whether flies are a good system in which to study neuronal polarity as a comprehensive analysis of

SUBMITTER: Rolls MM 

PROVIDER: S-EPMC1868948 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature