Association between the ACCN1 gene and multiple sclerosis in Central East Sardinia.

ABSTRACT: Multiple genome screens have been performed to identify regions in linkage or association with Multiple Sclerosis (MS, OMIM 126200), but little overlap has been found among them. This may be, in part, due to a low statistical power to detect small genetic effects and to genetic heterogeneity within and among the studied populations. Motivated by these considerations, we studied a very special population, namely that of Nuoro, Sardinia, Italy. This is an isolated, old, and genetically homogeneous population with high prevalence of MS. Our study sample includes both nuclear families and unrelated cases and controls. A multi-stage study design was adopted. In the first stage, microsatellites were typed in the 17q11.2 region, previously independently found to be in linkage with MS. One signifi

SUBMITTER: Bernardinelli L 

PROVIDER: S-EPMC1868958 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature