Ultraviolet-A radiation induces changes in cyclin G gene expression in mouse melanoma B16-F1 cells.

ABSTRACT:

Background

We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation.

Results

B16-F1 melanoma cells were exposed to a single UVA radiation dose of 8 J/cm2 and mRNA was isolated 4 h after the end of UVA exposure. Atlas Mouse Cancer 1.2 cDNA expression arrays were used for the large-scale screening to identify the genes involved in the regulation of carcinogenesis, tumor progression and metastasis. Physiologically relevant UVA dose induced differential expression in 9 genes in the UVA exposed melanoma cells as compared to the unexposed control cells. The expression of seven

SUBMITTER: Pastila R 

PROVIDER: S-EPMC1871570 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature