Hierarchical classification of functionally equivalent genes in prokaryotes.

ABSTRACT: Functional classification of genes represents a fundamental problem to many biological studies. Most of the existing classification schemes are based on the concepts of homology and orthology, which were originally introduced to study gene evolution but might not be the most appropriate for gene function prediction, particularly at high resolution level. We have recently developed a scheme for hierarchical classification of genes (HCGs) in prokaryotes. In the HCG scheme, the functional equivalence relationships among genes are first assessed through a careful application of both sequence similarity and genomic neighborhood information; and genes are then classified into a hierarchical structure of clusters, where genes in each cluster are functionally equivalent at some resolution level, a

SUBMITTER: Wu H 

PROVIDER: S-EPMC1874638 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature