Segmental polymorphisms in the proterminal regions of a subset of human chromosomes.

ABSTRACT: The subtelomeric domains of chromosomes are probably the most rapidly evolving structures of the human genome. The highly variable distribution of large duplicated subtelomeric segments has indicated that frequent exchanges between nonhomologous chromosomes may have been taking place during recent genome evolution. We have studied the extent and variability of such duplications using in situ hybridization techniques and a set of well-defined subtelomeric cosmid probes that identify discrete regions within the subtelomeric domain. In addition to reciprocal translocation and illegitimate recombination events that could explain the observed mosaic pattern of subtelomeric regions, it is likely that homology-based recombination mechanisms have also contributed to the spread of distal subtelomer

SUBMITTER: Der-Sarkissian H 

PROVIDER: S-EPMC187550 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature