Metastatic progression and gene expression between breast cancer cell lines from African American and Caucasian women.

ABSTRACT: African American (AA) women have a lower overall incidence of breast cancer than do Caucasian (CAU) women, but a higher overall mortality. Little is known as to why the incidence of breast cancer is lower yet mortality is higher in AA women. Many studies speculate that this is only a socio-economical problem. This investigation suggests the possibility that molecular mechanisms contribute to the increased mortality of AA women with breast cancer. This study investigates the expression of 14 genes which have been shown to play a role in cancer metastasis. Cell lines derived from AA and CAU patients were analyzed to demonstrate alterations in the transcription of genes known to be involved in cancer and the metastatic process. Total RNA was isolated from cell lines and analyzed by RT-PCR ana

SUBMITTER: Yancy HF 

PROVIDER: S-EPMC1876212 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature