Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.

ABSTRACT:

Background

The epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and differentiation. There are three well described polymorphisms that are associated with increased protein production in experimental systems: a polymorphic dinucleotide repeat (CA simple sequence repeat 1 [CA-SSR1]) in intron one (lower number of repeats) and two single nucleotide polymorphisms (SNPs) in the promoter region, -216 (G/T or T/T) and -191 (C/A or A/A). The objective of this study was to examine distributions of these three polymorphisms and their relationships to each other and to EGFR gene mutations and allelic imbalance (AI) in non-small cell lung cancers.

Methods and findings

W

SUBMITTER: Nomura M 

PROVIDER: S-EPMC1876407 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature