Transcriptional analysis of an immune-responsive serine protease from Indian malarial vector, Anopheles culicifacies.

ABSTRACT:

Background

The main vector for transmission of malaria in India is the Anopheles culicifacies mosquito species, a naturally selected subgroup of which is completely refractory (R) to transmission of the malaria parasite, Plasmodium vivax;

Results

Here, we report the molecular characterization of a serine protease (acsp30)-encoding gene from A. culicifacies, which was expressed in high abundance in the refractory strain compared to the susceptible (S) strain. The transcriptional upregulation of acsp30 upon Plasmodium challenge in the refractory strain coincided with ookinete invasion of mosquito midgut. Gene organization and primary sequence of acsp30 were identical in the R and S strains suggesting a divergent regulatory status of acsp30 in these strains. To examine this fur

SUBMITTER: Rodrigues J 

PROVIDER: S-EPMC1876469 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature