Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.

ABSTRACT:

Objectives

To compare the efficacy and safety of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) for treating uncomplicated falciparum malaria in Uganda.

Design

Randomized single-blinded clinical trial.

Setting

Apac, Uganda, an area of very high malaria transmission intensity.

Participants

Children aged 6 mo to 10 y with uncomplicated falciparum malaria.

Intervention

Treatment of malaria with AL or DP, each following standard 3-d dosing regimens.

Outcome measures

Risks of recurrent parasitemia at 28 and 42 d, unadjusted and adjusted by genotyping to distinguish recrudescences and new infections.

Results

Of 421 enrolled participants, 417 (99%) completed follow-up. The unadjusted risk of recurrent falciparum parasitemia w

SUBMITTER: Kamya MR 

PROVIDER: S-EPMC1876597 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature