Synaptic reorganization in subiculum and CA3 after early-life status epilepticus in the kainic acid rat model.

ABSTRACT:

Purpose

The immature rat brain is highly susceptible to seizures, but has a resistance to pathological changes induced by seizures as compared to adult rats. However, prolonged seizures during early-life enhance cellular injury and hyperexcitability induced by convulsive insults later in adulthood. The mechanisms underlying these phenomena are not understood. In adult models, the CA1 axons reorganize their projections to subiculum. Seizure induced plasticity in this pathway has not been investigated in immature seizure models, and may contribute to the vulnerability to later seizures.

Methods

On postnatal day 15, rats experienced convulsive status epilepticus with kainic acid (KA). Seizure induced plasticity was examined with Timm histochemistry and iontophoretic injections

SUBMITTER: Cross DJ 

PROVIDER: S-EPMC1876715 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature