Analysis of the effect of endogenous viral genes in the Smyth line chicken model for autoimmune vitiligo.

ABSTRACT: The Smyth line (SL) chicken, an animal model for autoimmune human vitiligo, is characterized by a spontaneous posthatch pigment loss, determined to be the result of an autoimmune phenomenon. Because endogenous virus (EV) genes have been reported to be associated with a number of autoimmune diseases of human and animal models, we designed this experiment to investigate the role of EV in the SL vitiligo by using the complete sequence of Rous-associated virus-2 as a probe for EV. An F(2) resource population was developed by the matings of SL and parental control (BL) chickens. Linkage disequilibrium between vitiligo and EV was apparent (16.2-kb SacI fragment, P

SUBMITTER: Sreekumar GP 

PROVIDER: S-EPMC1876847 | biostudies-literature | 2000 Mar

REPOSITORIES: biostudies-literature