A search engine to identify pathway genes from expression data on multiple organisms.

ABSTRACT:

Background

The completion of several genome projects showed that most genes have not yet been characterized, especially in multicellular organisms. Although most genes have unknown functions, a large collection of data is available describing their transcriptional activities under many different experimental conditions. In many cases, the coregulatation of a set of genes across a set of conditions can be used to infer roles for genes of unknown function.

Results

We developed a search engine, the Multiple-Species Gene Recommender (MSGR), which scans gene expression datasets from multiple organisms to identify genes that participate in a genetic pathway. The MSGR takes a query consisting of a list of genes that function together in a genetic pathway from one of six organisms:

SUBMITTER: Chen C 

PROVIDER: S-EPMC1878502 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature