Multiple non-collinear TF-map alignments of promoter regions.

ABSTRACT:

Background

The analysis of the promoter sequence of genes with similar expression patterns is a basic tool to annotate common regulatory elements. Multiple sequence alignments are on the basis of most comparative approaches. The characterization of regulatory regions from co-expressed genes at the sequence level, however, does not yield satisfactory results in many occasions as promoter regions of genes sharing similar expression programs often do not show nucleotide sequence conservation.

Results

In a recent approach to circumvent this limitation, we proposed to align the maps of predicted transcription factors (referred as TF-maps) instead of the nucleotide sequence of two related promoters, taking into account the label of the corresponding factor and the position in the

SUBMITTER: Blanco E 

PROVIDER: S-EPMC1878506 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature