TAP score: torsion angle propensity normalization applied to local protein structure evaluation.

ABSTRACT:

Background

Experimentally determined protein structures may contain errors and require validation. Conformational criteria based on the Ramachandran plot are mainly used to distinguish between distorted and adequately refined models. While the readily available criteria are sufficient to detect totally wrong structures, establishing the more subtle differences between plausible structures remains more challenging.

Results

A new criterion, called TAP score, measuring local sequence to structure fitness based on torsion angle propensities normalized against the global minimum and maximum is introduced. It is shown to be more accurate than previous methods at estimating the validity of a protein model in terms of commonly used experimental quality parameters on two test sets re

SUBMITTER: Tosatto SC 

PROVIDER: S-EPMC1878508 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature