Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.

ABSTRACT: The Hedgehog (Hh) and Notch signal transduction pathways control a variety of developmental processes including cell fate choice, differentiation, proliferation, patterning and boundary formation. Because many components of these pathways are conserved, it was predicted and confirmed that pathway components are largely intact in the sea urchin genome. Spatial and temporal location of these pathways in the embryo, and their function in development offer added insight into their mechanistic contributions. Accordingly, all major components of both pathways were identified and annotated in the sea urchin Strongylocentrotus purpuratus genome and the embryonic expression of key components was explored. Relationships of the pathway components, and modifiers predicted from the annotation of S. pur

SUBMITTER: Walton KD 

PROVIDER: S-EPMC1880897 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature