Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.

ABSTRACT:

Background

The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk of cancer in XP patients, we hypothesized that inherited sequence variations in XPC may alter DNA repair and thus susceptibility to cancer.

Methods

In this hospital-based case-control study, we investigated five XPC tagging, common single nucleotide polymorphisms (tagging SNPs) in 1,010 patients with newly diagnosed lung cancer and 1,011 matched cancer free controls in a Chinese population.

Results

In individual tagging SNP analysis, we found that rs3731055AG+AA variant genotypes were associated with a significantly decreased risk of lung adenocarc

SUBMITTER: Bai Y 

PROVIDER: S-EPMC1884164 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature